Sponsor(s):China Sport Science Society
12 issues per year
Current Issue: Issue 06, 2019
China Sport Science, launched in 1981, is the official publication of China Sport Science Society and hosted by China Sport Science Society. General Administration of Sport is its authorities concerned. Under the new background of sports development, the journal aims at publishing more high-level research results which reveals the development of sports science in China. More academically innovative and pratically significant papers are expected to inject new vitality into this influential and comprehensive sports academic journal.
Execute editor in chief
YANG Hua, DU Li-jun, WANG Qing, LI Xiao-xian
Editorial board of members
WANG Jin, WANG Jia-hong, CONG Hu-ping, FENG Lian-shi, LV Wan-gang, REN Hai, JIANG Chong-min, LIU Da-qing, LIU Yu, LIU Xing, LI Guo-ping, LI Hong-jiang, JI Liu, SU Ming-li, CHEN Wei, CHEN Pei-jie, ZHANG Li-wei, ZHANG Zhong-qiu, WU Mou-tian, ZHAO Guang-sheng, ZHONG Bing-shu, YAO Jia-xin, AO Ying-fang, CHANG Yun, HUANG Han-sheng, ZHANG Jian-cheng, XIE Min-hao, BAO Ming-xiao
Interval Training Modulates Pathological Cardiac Hypertrophy in Spontaneously Hypertensive Rats: Relationship between Exercise Intensity and Health Effect
China Sport Science,2019,Vol 39,No. 06
Objective: To compare the effects of long-term interval training with different intensities on pathological cardiac hypertrophy in spontaneously hypertensive rats (SHRs), and explore the relationship between exercise intensity and health effect. Methods: Forty-five male SHRs were randomly divided into a sedentary (SHR-SED) group, a moderate-intensity interval training (SHR-MIIT) group, and a high-intensity interval training (SHR-HIIT) group; fifteen age- and sex-matched Wistar-Kyoto (WKY) rats were set as a normotensive group. Rats in SHR-MIIT and SHR-HIIT groups were performed 18 weeks of MIIT or HIIT training, respectively, and WKY and SHR-SED groups were kept sedentary during experiment. Forty-eight hours after the last training, the caudal artery pressure was measured by using non-invasive blood pressure tester; the cardiac structure and function were detected by using echocardiogram; the myocardial cross sectional area (CSA) and interstitial collagen volumetric fraction (CVF) were obtained by H&E and Masson staining; RT-PCR was conducted to measure the mRNA levels of atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP) and β-myosin heavy chain (β-MHC); Western blotting was conducted to measure the protein levels of calcineurin/nuclear factor of activation T cell (Cn/NFAT) and phosphoinositide 3-kinase/Akt (PI3-K/Akt). Results: (1) Cardiac morphology and structure: The left ventricle was concentric hypertrophy (i.e., cardiac chamber was constricted; ventricular wall was thickened; CSA was increased) and the CVF was increased (P < 0.05) in SHR-SED group; the left ventricle was eccentric hypertrophy (i.e., cardiac chamber was dilatated, and ventricular wall was thickened) and the CVF was reduced (P < 0.05) in SHR-MIIT group; the SHR-HIIT group showed eccentric hypertrophy, with dilated cardiac chamber, thinner ventricular wall was thinner, and increased CVF (P < 0.05). (2) Cardiac function: The left ventricular ejection fraction (LVEF) was decreased (P < 0.05) in SHR-SED group; the LVEF was raised (P < 0.05) in SHR-MIIT group but decreased (P < 0.05) in SHR-HIIT group compared with SHR-SED group. (3) Fetal gene expression: The mRNA levels of ANP, BNP, and β-MHC was up-regulated (P < 0.05) in SHR-SED group; compared with those in SHR-SED group, all genes were down-regulated (P < 0.05) in SHR-MIIT group while BNP and β-MHC were up-regulated (P < 0.05) in SHR-HIIT group. (4) Protein expression of cardiac hypertrophy: the CnAβ was increased (P < 0.05) and the p-NFATc3/t-NFATc3 ratio was decreased (P < 0.05), but the PI3-K (p110α) and p-Akt/t-Akt ratio showed no significant difference (P > 0.05) in SHR-SED group; compared with those in SHR-SED group, the CnAβ was reduced (P < 0.05), and the p-NFATc3/t-NFATc3 ratio, PI3-K (p110α), and p-Akt/t-Akt ratio were raised (P < 0.05) in SHR-MIIT group; in addition, the CnAβ, PI3-K (p110α), and p-Akt/t-Akt ratio were increased (P < 0.05), and the pNFATc3/t-NFATc3 ratio was decreased (P < 0.05) in SHR-HIIT group. Conclusion: The health effect of long-term interval training on hypertension was dependent on exercise intensity. MIIT transformed the pathological into physiological hypertrophy to improve the cardiac function, but HIIT exacerbated cardiac remodeling and accelerated heart failure in SHR. The mechanism was considered to be related to the different regulation of interval training on myocardial collagen metabolism, fetal gene expression as well as the regulation of Cn/NFAT and PI3-K/Akt. Therefore, moderate-intensity exercise is still an optimal mode for hypertension patients to rehabilitation in clinical. However, the security and efficiency of HIIT should be further verified.
Actuality and ideality of symbiotic relationship between sports and medicine against the backdrop of Healthy China strategy
China Sport Science,2019,Vol 39,No. 06
Against the backdrop of healthy China strategy, the quality parameters of sports and medicine symbiotic units are compatible. The two symbiotic units have symbiotic interface, can bring symbiotic benefits, and can form asymmetric positive symbiotic relationships. However, the health service mainly depends on medicine in China, the reality state of sports and medicine shows that the correlation is low, and the symbiotic mode is asymmetric continuous reciprocal symbiosis. The communication of symbiotic interface is still not smooth, which limits the development of deep integration of sports and medicine. Based on the theory of social symbiosis, this paper constructed a five-dimensional symbiotic mechanism of collaborative linkage, joint consultation, interest balance, policy guarantee and integrated development, and proposed that the conceptual consensus should be reached in the field of physical education and medicine, and the community of interests should be fostered, so as to improve the symbiosis degree of sports and medicine. At the same time, this paper pointed out that the symbiotic mode of sports and medicine should be changed to form an integrated symmetric and mutually beneficial symbiotic mode; the symbiotic interface between sports and medicine should be optimized through support of national policies; the symbiotic environment of sports and medicine should be improved to promote the mutually complementary, interdependent, co-evolutionary and mutually developing win-win symbiotic relationship between sports and medicine.