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Brief

Chinese Traditional and Herbal Drugs is supervised by Chinese Pharmaceutical Association and sponsored by Tianjin Institute of Pharmaceutical Research and Chinese Pharmaceutical Association. Launched in 1970, the journal is an academic journal with a broad scope in publishing research papers, brief reports, reviews, dissertations, and special treatises on the recent achievements of basic study, production, quality control, and clinic application on traditional Chinese medicine and Chinese materia medica. The journal is included in CA, JST and CSCD.
Editorial Board

Editor-in-Chief
Tang Lida

Director
Chen Changqing

Optimization of processing technology for ointment with mixed excipients of oxhide gelatin and honey by central composite design-response surface methodology

XI Xiao-hu;LIU Xia;TONG Li-guo

Chinese Traditional and Herbal Drugs,2016,Vol 47,No. 08

Preparation of hydrogel matrix sustained-release tablets of resveratrol-solid lipid nanoparticles

WU Xian-chuang;HAO Hai-jun;SONG Xiao-yong;ZHANG Yong-zhou;LIU Yu-xin;ZHANG Hong-qin

Chinese Traditional and Herbal Drugs,2016,Vol 47,No. 08

?Inhibition and machanisms of total saponins from Panax notoginseng on apoptosis of hippocampal CA1 subfield neurons of rats following global cerebral ischemia

HE Xu;GE Jin-wen;DENG Chang-qing;GUO Tai-ping;PAN Ai-hua;LI Zhi-yuan

Chinese Traditional and Herbal Drugs,2016,Vol 47,No. 08

Objective To explore whether total saponins of Panax notoginseng (TSPN) can protect hippocampal CA1 subfield neurons against apoptosis following global cerebral ischemia via up-regulating the Bcl-2/Bax ratio and preventing Caspase-3 activation. Methods Using four-vessel occlusion method to build the global cerebral ischemia model and the ischemia time was 30 min. All rats were divided into Sham group, vehicle group, and different doses (25, 50, 75, and 100 mg/kg) of TSPN groups. The rats in TSPN groups were ip administered with TSPN. The dose of TSPN was suspended in 0.9% saline (10 g/L), while rats in vehicle group were treated with equal volume of 0.9% saline, one injection per day. Compared the survival rate and hippocampal CA1 subfield neuronal density by Nissl staining after reperfusion of 14 d to make sure the best dose of TSPN for neuroprotection. Then to evaluate the neurological score and investigate the expression level of the Caspase-3, Bcl-2, and Bax in the hippocampus CA1 region at days 1, 3, 7, and 14 post-ischemia by immunohistochemistry; In addition, the Western-blotting was adopted to test the protein level of these three proteins. Results The survival rate of the rats in 75 mg/kg TSPN groups was 100%, and its neuronal density was significantly higher than that in vehicle group and other doses of TSPN groups (P < 0.05); The neurological score in TSPN group was significantly less than that in vehicle group (P < 0.01); The Caspase-3 neuronal density in the CA1 subfield of TSPN group on days 7 and 14 was significantly less than that in vehicle group (P < 0.001); The statistical meaning existed about the protein level of Caspase-3 with molecular weight of 20 000 on days 3, 7, and 14 and 17 000 on days 7 and 14 in two groups (P < 0.001). The neuronal density of Bcl-2 cells in the CA1 subfield and Bcl-2 protein level in the hippocampus of TSPN group at days 7 and 14 was significantly higher than that in vehicle group (P < 0.001); Besides, the Bax neuronal density at days 7 and 14 was significantly lower than that in vehicle group (P < 0.001); And its protein level of the hippocampus was less than that in vehicle group at days 3, 7 and 14 (P < 0.001). The results of ratio of Bcl-2/Bax from not only the neuronal density but also the protein expression demonstrated that the Bcl-2/Bax ratio in TSPN group was significantly higher than that in vehicle groups on days 7 and 14 (P < 0.001). Conclusion TSPN can protect the hippocampal CA1 subfield neurons against apoptosis following global cerebral ischemia in adult rats via up-regulating the Bcl-2/Bax ratio and preventing Caspase-3 activation.

Application of blending raw materials in quality consistency control of Qianlie Shule Capsule

YIN Wen-jing;WEI Hui-zhen;LIU Sheng-nan;JIN Hao-xin;DUAN Yi-qian;YANG Shi-lin;ZHU Yi-lei;LIU Wen-xia;RAO Yi

Chinese Traditional and Herbal Drugs,2016,Vol 47,No. 08

Conversion mechanism of 5-hydroxymethylfurfural in process of bran-fried Atractylodes lancea

LIU Miao-miao;CHEN Xiang-sheng;CHEN Qi-yao;LIU Yan-ju;FU Wei;XU An-an;RONG Yan-fen

Chinese Traditional and Herbal Drugs,2016,Vol 47,No. 08