Effects of moxibustion at Shenshu (BL 23) on sex hormones and AMH levels of perimenopausal women under sub-health condition

SHEN Jie1 SHEN Meihong1 LI Zhongren1 ZHANG Rongli1 LI Xia1 AI Bingwei2

(1.The Second Clinical Medical School, Nanjing University of Chinese Medicine, Nanjing, Jiangsu Province, China 210023)
(2.The Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu Province, China 210029)

【Abstract】Objective To compare the effects of moxibustion at Shenshu (BL 23) and oral administration of Vitamin E on life quality of perimenopausal women under sub-health condition and the relative mechanism, aiming to provide clinical evidence for the application of moxibustion to the health care of women under sub-health condition. Methods Sixty participants were randomly divided into the moxibustion group and the medication group, with 30 cases in each group. The subjects in the moxibustion group were treated with mild moxibustion at bilateral Shenshu (BL 23) for 15 minutes, once a day and five days as a course of treatment. Four continuous courses of treatment were given with an interval of two days. The subjects in the medication group were treated with oral administration of soft capsule of Vitamin E, one capsule a day for continuous 28 days. The quality of life score and serum levels of sex hormones, anti-Mullerian hormone (AMH) and inhibin B (INHB) of subjects in the two groups were measured before and after the intervention. Results ① The scores of life quality in the two groups were both increased significantly after the treatment (both P < 0.01), and the result in the moxibustion group was superior to that of the medication group (P < 0.05). ② The serum levels of estradiol (E2) and progesterone in the moxibustion group were increased remarkably after the treatment, especially for the non-menopausal subjects (both P < 0.01). ③ After moxibustion, the serum level of AMH was improved obviously (P < 0.01), but there was no statistical difference in INHB level (P > 0.05). Conclusion Moxibustion can effectively improve the life quality of perimenopausal women under sub-health condition, regulate the levels of sex hormones and AMH, improve ovarian reserve function, and delay ovarian aging.

【Keywords】 perimenopause; sub-health; acupuncture and moxibustion; sex hormone; anti-Mullerian hormone (AMH);


【Funds】 Scientific and Technological Program Supported by Jiangsu Administration of Traditional Chinese Medicine: LZ13008 Young Scientists Fund of the Natural Science Foundation of Nanjing University of Chinese Medicine: 13XZR15

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This Article



Vol 37, No. 04, Pages 381-385

April 2017


Article Outline


  • 1 Clinical materials
  • 2 Treatment methods
  • 3 Observation of curative effects
  • 4 Discussion
  • References