Acupuncture for female depression: a randomized controlled trial

LIU Jian1 WANG Aiai1 NIE Guangning1 WANG Xiaoyun1 HUANG Jian1

(1.Department of Gynecology, Guangdong Provincial Hospital of TCM, Guangzhou, China 510120)

【Abstract】Objective to observe the effect differences and safety between acupuncture and sham acupuncture for female depression on the basis of conventional western medicine therapy. Methods Forty-two patients with depression who met the criteria were randomly assigned into an observation group and a control group, 21 patients in each group. The basic treatment in the two groups was fluoxetine. The patients in the observation group were treated with acupuncture at Zhongwan (CV 12), Xiawan (CV 10), Qihai (CV 6), Guanyuan (CV 4) and bilateral Shangqu (KI 17). Sham acupuncture was used at the above points in the control group. The treatment was given once a day on the first 3 days and once every 3 days after that, totally for 8 weeks. The scores of self-rating depression scale (SDS) and Montgomery Asberg depression rating scale (MADRS) were compared before and after 4-week and 8-week treatment in the two groups. The effects and adverse reactions were evaluated. Results After 4-week and 8-week treatment, the SDS and MADRS scores were significantly lower than those before treatment in the two groups(all P< 0.05), and the scores in the observation group were lower than those in the control group (both P < 0.05). The improvements of SDS and MADRS scores in the observation group before and after treatment were better than those in the control group (both P < 0.05). The total effective rates of SDS, MADRS scores were 85.7% (18/21), 90.5% (19/21) in the observation group, which were better than 38.1% (8/21), 57.1% (12/21) in the control group (both P < 0.05). The adverse reactions in the observation group were significantly lower than those in the control group (P < 0.05). Conclusion Acupuncture combined with fluoxetine are effective and safe for female depression.

【Keywords】 female depression; acupuncture; fluoxetine; self-rating depression scale (SDS); randomized controlled trial (RCT);

【DOI】

【Funds】 Grants from the Alternative Medicine Program of Daegu in South Korea Project of Guangdong Provincial Bureau of Traditional Chinese Medicine(20162065) Non-Profit Study and Capability Building Special Fund Support Project of Guangdong Provincial Department of Science and Technology, China in the Year 2014 (Second batch) (2014 A 020221066)

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    References

    [1] Kwon CS, Lee JH. Prevalence, risk factors, quality of life, and health-care seeking behaviors of female urinary incontinence: results from the 4th Korean National Health and Nutrition Examination Survey VI (2007–2009) [J]. Int Neurourol J, 2014, 18 (1): 31–36.

    [2] Oh DH, Kim SA, Lee HY, et al. Prevalence and correlates of depressive symptoms in Korean adults: results of a 2009 Korean community health survey [J]. J Korean Med Sci, 2013, 28 (1): 128–135.

    [3] Abate KH. Gender disparity in prevalence of depression among patient population: a systematic review [J]. Ethiop J Health Sci, 2013, 23 (3): 283–288.

    [4] Cheg QL, Xie SF, Huang YQ, et al. The cross–section survey on prevalence of depressive disorder in Dalian [J]. Med Philos, 2010, 78 (4): 56–58.

    [5] FAVA M. Diagnosis and definition of treatment-resistant depression [J]. Biol Psychiatry, 2003, 15 (53): 649–659.

    [6] Effective Health Care Bulletin.Improving the recognition and management of depression in primary care. York: Centre for Reviews and Dissemination [M]. York: University of York, 2005: 1–12.

    [7] Carulla LS, Reed GM, Vaez-azizi LM, et al. Intellectual developmental disorders: towards a new name, definition and framework for “mental retardation/intellectual disability” inICD-11[J]. World Psychiatry, 2011, 10 (3): 175–180.

    [8] ZUNG WWK. A Self-Rating Depression Scale [J]. Arch Gen Psychiatry, 1965, 12 (1): 63–70.

    [9] Montgomery SA, Rani SJ, McAuley R, et al. The antidepressant efficacy of zimelidine and maprotiline [J]. Acta Psychiatr Scand Suppl, 1981, 290: 219–224.

    [10] Wang H, Luo J, Rang JF. 氟伏沙明和氟西汀治疗66例老年期抑郁症的对照分析 [J]. Chongqing Medical Journal, 2012, 22 (5): 185–189 (in Chinese).

    [11] Kessler RC, Soukup J, Davis RB, et al. Eisenberg DM: The use of complementary and alternative therapies to treat anxiety and depression in the United States [J]. Am J Psychiatry, 2011, 158 (2): 289–294.

    [12] Hunt KJ, Coelho HF, Wider B, et al. Complementary and alternative medicine use in England: results from a national survey [J]. Int J Clin Pract, 2010, 64 (11): 1496.

    [13] Smith CA, Hay PP, Macpherson H. Acupuncture for depression [J]. Cochrane Database Syst Rev, 2010, 48 (1): 40–46.

    [14] Zhou XF, LI Y, Zhou ZH, et al. Clinical observasion of acupuncture in patients with depression and its impact on serum 5-HT [J]. Chinese Acupuncture & Moxibustion, 2015, 35 (2): 123–126 (in Chinese).

    [15] Kondo T, Tokunaga S, Sugahara H, et al. Qi-deficiency, Qistagnation, Qi-flowback, blood deficiency, and fluid retention in patients with depression, psychiatric disorders, or psychosomatic disorders [J]. Psychology, 2011, 20 (2): 643–659.

    [16] Chen LL. Research on syndrome differentiation of depression based on literature data [D]. Jinan: Shandong University of Traditional Chinese Medicine, 2016 (in Chinese).

    [17] Sui YY, Zhong Z, Wang JQ, et al. 针刺结合西药治疗抑郁症的优势分析 [J]. Guiding Journal of Traditional Chinese Medicine and Pharmacy, 2017, 23 (12): 90–92 (in Chinese).

    [18] Xu L, Wang LL. Clinical observation on depression treated by electroacupuncture combined with western medicine [J]. Chinese Acupuncture & Moxibustion, 2011, 31 (9): 779–782.

    [19] Zheng M, Lin YH, Zhang JB, et al. Clinical Observation of Acupuncture Combined with Antidepressants for 44 Cases of Depression [J]. Journal of Traditional Chinese Medicine, 2012, 53 (11): 927–932 (in Chinese).

    [20] Xu YM, Huang WH, Chen W. 柴胡疏肝散联合针灸治疗原发性抑郁症疗效观察 [J]. Liaoning Journal of Traditional Chinese Medicine, 2016, 43 (12): 2590–2592 (in Chinese).

    [21] Cuixia Z, Xiao C, Yongshan H, et al. Effect of combinedacupuncture with Chinese medicine on overall function of patients with post-stroke depression [J]. J Acup Tuina Sci, 2012, 10 (2): 99–103.

This Article

ISSN:0255-2930

CN:11-2024/R

Vol 38, No. 04, Pages 375-378

April 2018

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Article Outline

Abstract

  • 1 Clinical data
  • 2 Treatment methods
  • 3 Observation of effectiveness
  • 4 Discussion
  • References