Analysis of CiteSpace knowledge map for traditional Chinese medicine prevention and treatment of cerebral small vessel diseases

LI Ting-ting1,2 SUN Qian-hui3 WANG Bo-yuan1 ZHANG Hong-rui1,2 ZHENG Xiang-yi1,2 GAO Ying1,2

(1.Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, China 100700)
(2.Chinese Medicine Key Research Room of Encephalopathy Syndrome and Treatment of National Administration of Traditional Chinese Medicine, Beijing, China 100700)
(3.Guang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China 100053)

【Abstract】This study aimed to analyze the research on the prevention and treatment of cerebral small vessel diseases (CSVDs) with traditional Chinese medicine (TCM) based on knowledge map, and to preliminarily explore the research hotspots and trends. To be specific, articles on TCM treatment of CSVDs in CNKI, Wanfang Data, and VIP (from establishment to November 2021) were retrieved, followed by bibliometric analysis. Then CiteSpace 5.7 R4 and Gephi were employed for generation of maps on annual number of articles, author cooperation, institution cooperation, keyword co-occurrence, keyword clustering, and keyword emergence. A total of 106 eligible articles were screened out, and the annual number of articles presented a steady upward trend. A total of 277 authors were included in the author cooperation network, among whom CHEN Zhigang published the most articles. A total of 87 institutions were included in the institution cooperation network, among which Dongfang Hospital of Beijing University of Chinese Medicine showed the most frequent cooperation with other institutions. Keyword clustering showed that research on the TCM treatment of CSVDs mainly focused on five aspects: related disease research, neurological function deficits, disease nature and location in TCM, TCM treatment methods, and formulas. The prevention and treatment of CSVDs with TCM in China has been developing steadily in the past ten years, and TCM has unique advantages in the prevention and treatment of this disease. The knowledge maps vividly demonstrated the development and research hotspots and trends in this field. The results were expected to provide a reference for further research in this field.

【Keywords】 traditional Chinese medicine; cerebral small vessel disease (CSVD); CiteSpace; Gephi;

【DOI】

【Funds】 Chinese Medicine Inheritance and Innovation “100 Million” Talent Project (Qihuang Scholar)—National Chinese Medicine Leading Talent Program ([2018] 12)

Download this article

    References

    [1] PANTONI L. Cerebral small vessel disease: from pathogenesis and clinical characteristics to therapeutic challenges [J]. Lancet Neurol, 2010, 9 (7): 689.

    [2] GROSSET L, JOUVENT E. Cerebral small-vessel diseases: a look back from 1991 to today [J]. Cerebrovasc Dis, 2022, 51 (2): 131.

    [3] VERMEER S E, PRINS N D, HEIJER T, et al. A prospective study of cerebral white matter abnormalities in older people with gait dysfunction [J]. Neurology, 2001, 57 (6): 990.

    [4] VERMEER S E, LONGSTRETH W T, KOUDSTAAL P J. Silent brain infarcts: a systematic review [J]. Lancet Neurol, 2007, 6: 611.

    [5] RUSSO E, LEO A, SCICCHITANO F, et al. Cerebral small vessel disease predisposes to temporal lobe epilepsy in spontaneously hypertensive rats [J]. Brain Res Bull, 2017, 130: 245.

    [6] GROOT J C, LEEUW F E, OUDKERK M, et al. Cerebral white matter lesions and cognitive function: the rotterdam scan study [J]. Ann Neurol, 2000, 47: 145.

    [7] HOLST H M, UDEN I W, TULADHAR A M, et al. Cerebral small vessel disease and incident parkinsonism: the RUN DMC study [J]. Neurology, 2015, 85: 1569.

    [8] WARDLAW J M, SMITH C, DICHGANS M. Mechanisms of sporadic cerebral small vessel disease: insights from neuroimaging [J]. Lancet Neurol, 2013, 12: 483.

    [9] BERKHEMER O A, FRANSEN P S, BEUMER D, et al. A randomized trial of intraarterial treatment for acute ischemic stroke [J]. N Engl J Med, 2015, 372: 11.

    [10] CAMPBELL B C, MITCHELL P J, KLEINIG T J, et al. Endovascular therapy for ischemic stroke with perfusion-imaging selection [J]. N Engl J Med, 2015, 372: 1009.

    [11] JOVIN T G, CHAMORRO A, COBO E, et al. Thrombectomy within 8 hours after symptom onset in ischemic stroke [J]. N Engl J Med, 2015, 372: 2296.

    [12] ZENG Z L, TONG L. LIU S H, et al. Hotspots and trends of Ophiopogonis Radix based on CiteSpace knowledge map [J].China Journal of Chinese Materia Medica, 2021, 46 (24): 6549 (in Chinese).

    [13] CHENGFENG J M, WANG L X, XIE Y M. Visualization of research on Chinese medicine-induced kidney injury by CiteSpace [J]. China Journal of Chinese Materia Medica, 2021, 46 (21): 5475 (in Chinese).

    [14] XIE L H, LIN X Y, LI X, et al. Visualization analysis of traditional Chinese medicine for neurogenesis research based on CiteSpace [J]. China Journal of Chinese Materia Medica, 2021, 46 (17): 4555 (in Chinese).

    [15] LIU Y, DU Y. 网络数据可视化与分析利器 (Gephi中文教程) [M]. Beijing: Publishing House of Electronics Industry, 2017 (in Chinese).

    [16] ZHU X Y, WANG Y Q, LI N N, et al. 基于“络损髓伤”理论治疗缺血性脑白质病分析 [J]. Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease, 2021, 19 (7): 1217 (in Chinese).

    [17] ZHANG X Y, LIAO X, LIU X M, ET AL. Analysis of outcomes of randomized controlled trial on compound Chinese herbal medicine formulas in treatment of vascular cognitive impairment caused by cerebral small vessel [J]. China Journal of Chinese Materia Medica, 2020, 45 (23): 5804 (in Chinese).

    [18] HOU X B, ZHANG Y L, LIU M, et al. Impact of acupuncture on functional magnetic resonance imaging in leukoaraiosis with mild cognitive impairment [J]. World Journal of Integrated Traditional and Western Medicine, 2010, 5 (2): 122 (in Chinese).

    [19] ZHANG Y X, ZHANG Y L, JIN X L, et al. 中医综合干预方案治疗脑白质疏松轻度认知障碍疗效评价研究 [J]. Liaoning Journal of Traditional Chinese Medicine, 2014, 41 (11): 2286 (in Chinese).

    [20] JIN X L, ZHANG Y L, GAO F, et al. 脑白质疏松伴轻度认知障碍危险因素初探 [J]. Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease, 2009, 7 (3): 276 (in Chinese).

    [21] ZHANG Y L, JIN X L, CHEN Z G, et al. Preliminary study on the syndrome factors of leukoaraiosis with mild cognitive impairment [J]. Journal of Traditional Chinese Medicine, 2008, 49 (12): 1103 (in Chinese).

    [22] LI J H, YANG N. Discussion on treating cerebral small vessel disease with the method of resolving stasis and removing obstruction of collateral based on “collateral-sweat pore” [J]. Global Traditional Chinese Medicine, 2021, 14 (8): 1407 (in Chinese).

    [23] HUANG R C, LI J T, YANG N. Near and long term curative effect of Huayu Tongluo Decoction on cognitive dysfunction caused by cerebral small vessel disease [J]. Modern Journal of Integrated Traditional Chinese and Western Medicine, 2017, 26 (3): 259 (in Chinese).

    [24] CHEN C L, YANG N, CHEN Z B, et al. 脑小血管患者实施中医八段锦康复干预对运动功能及日常生活能力的改善作用 [J]. Heilongjiang Journal of Traditional Chinese Medicine, 2021, 50 (3): 112 (in Chinese).

    [25] ZHANG S X, XU H Y, BI J X, et al. 基于“肾藏精生髓”理论探讨脑小血管病所致认知功能障碍 [J]. Hunan Journal of Traditional Chinese Medicine, 2018, 34 (11): 107 (in Chinese).

    [26] ZHANG S X, BI J X, ZHOU L M. Effect of Jiawei Dihuang Decoction (加味地黄饮) on serum MMP-9, hs-CRP and SOD in patients with cognitive impairment of cerebral small vessel disease [J]. Guiding Journal of Traditional Chinese Medicine and Pharmacy, 2020, 26 (14): 40 (in Chinese).

    [27] SHI J J, BO R Q, HU Y H, et al. Visualization analysis of Chinese medicine guidance based on Citespace [J]. Guiding Journal of Traditional Chinese Medicine and Pharmacy, 2018, 15 (4): 5 (in Chinese).

    [28] HAO J S. Research on semi-automatically constructing domain ontology hierarchy using keywords clustering [J]. Information Science, 2016, 34 (4): 59 (in Chinese).

    [29] WARDLAW J M, SMITH C, DICHGANS M. Small vessel disease: mechanisms and clinical implications [J]. Lancet Neurol, 2019, 18 (7): 684.

    [30] LI Y, SUN J B. Investigation on the pathogenesis of cerebral small vessel disease from “kidney deficiency-dumai deficiency and brain empty” [J]. World Science and Technology (Modernization of Traditional Chinese Medicine), 2019, 21 (1): 5 (in Chinese).

    [31] LI J H, HU Y Q, TANG N. Significance of preventive strategy of Chinese medicine in cerebral small vessel disease [J]. China Journal of Traditional Chinese Medicine and Pharmacy, 2020, 35 (12): 6087 (in Chinese).

    [32] ZHAO Y H, TANG Y H, WEN M, et al. Effect of “Tongxinluo” on cerebral microcirculation disturbance in acute ischemic stroke rats [J]. Acta Universitatis Traditionis Medicalis Sinensis Pharmacologiaeque Shanghai, 2006, 20 (3): 37 (in Chinese).

    [33] LIU C Y, ZHOU L, LIU B W, et al. 中西医结合治疗CSVD [J]. Journal of Chinese Medicine, 2020, 35 (5): 998 (in Chinese).

    [34] YU T Y, XIE J R, HUANG Q. 真中风与类中风概念分类浅述 [J]. Chinese Journal of Ethnomedicine and Ethnopharmacy, 2015, 24 (15): 44 (in Chinese).

    [35] HASSAN A, HUNT B J, SULLIVAN M, et al. Homocysteine is a risk factor for cerebral small vessel disease, acting via endothelial dysfunction [J]. Brain, 2004, 127 (Pt 1): 212.

    [36] DING Y, ZHAO Z. The research progress on gait disorders in cerebral small vessel disease [J]. Chinese Journal of Practical Nervous Diseases, 2020, 23 (14): 1267 (in Chinese).

    [37] MAKIN S D J, TURPIN S, DENNIS M S, et al. Cognitive impairment after lacunar stroke: systematic review and Meta-analysis of incidence, prevalence and comparison with other stroke subtypes [J]. J Neurol Neurosurg Psychiatry, 2013, 84 (8): 893.

    [38] ZHAO X L, LI J C, FAN J P, et al. Effect of Tongshen Funao Pill on homocysteine level in patients with cerebral small vessel cognitive impairment [J]. Chinese Medicine Modern Distance Education of China, 2017, 15 (8): 48 (in Chinese).

    [39] CAO Y F, ZHONG J G, GUO H M. Professor GUO Hongmin’s experience in treating NDVCI-CSVD with Yangyin Heyu Tongqiao Decoction [J]. Information on Traditional Chinese Medicine, 2018, 35 (6): 89 (in Chinese).

    [40] CHEN G, ZHOU H J, FU W Y, et al. Clinical effect of modified Rehmanniae Cold Decoction on cognitive disorder caused by cerebral small vessel disease and its impact on neurological function, inflammatory reaction and oxidative stress [J]. Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease, 2019, 27 (6): 78 (in Chinese).

This Article

ISSN:1001-5302

CN:11-2272/R

Vol , No. 08, Pages 2228-2236

January 2022

Downloads:0

Share
Article Outline

Abstract

  • 1 Data and methods
  • 2 Results
  • 3 Summary
  • References