Never ignore vascular senescence, and the three herbs help to cope with it easily

May. 20,2022
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China has entered an aging society, and the increasing aging population makes delaying senescence and reducing senescence-related diseases one of the most urgent health problems in the world. Vascular senescence is a key link in the senescence process, which can accelerate the senescence progress of the body and induce cardiovascular diseases, stroke, diabetes and other related diseases. The degree of vascular senescence can be considered as a key factor determining the health status of the elderly. How to prevent vascular senescence is an issue of great concern to the public and scientists.

Ginseng Radix et Rhizoma, Notoginseng Radix et Rhizoma and Chuanxiong Rhizoma can replenish qi and activate blood. Their active ingredients have the functions of dilating blood vessels, protecting vascular endothelial cells and regulating vasoactive substances. According to the available studies, their extract can delay natural senescence and vascular senescence in rats and mice by inhibiting oxidative stress pathway and alleviate the replicative senescence of vascular endothelial cells and smooth muscle cells. The mechanism of cell autophagy, which removes unnecessary or dysfunctional components and reuses energy, is similar to that of Chinese herbal medicines in replenishing qi, activating blood and dispelling stasis to promote regeneration. Can the extract of Ginseng Radix et Rhizoma, Notoginseng Radix et Rhizoma and Chuanxiong Rhizoma delay the senescence of vascular endothelial cells through cell autophagy?

In the research report “Mechanism of Extract of Ginseng Radix et Rhizoma, Notoginseng Radix et Rhizoma and Chuanxiong Rhizoma on SIRT1 Autophagy Pathway of Endothelial Cell Senescence Induced by Hydrogen Peroxide” published by China Journal of Chinese Materia Medica, the authors observed the effect of the extract of Ginseng Radix et Rhizoma, Notoginseng Radix et Rhizoma and Chuanxiong Rhizoma on the SIRT1 autophagy pathway of vascular endothelial cells exposed to hydrogen peroxide. According to the results, the extract can delay the senescence of vascular endothelial cells and significantly change the autophagy flux and the expression of related proteins SIRT1, LC3Ⅱ, and p62, increasing the autophagy level. EX527 weakened the effect of Chinese herbal medicines in delaying vascular senescence. The study indicates that extract of Ginseng Radix et Rhizoma, Notoginseng Radix et Rhizoma and Chuanxiong Rhizoma may delay the senescence of vascular endothelial cells through the SIRT1 autophagy pathway.

This study was supported by the National Natural Science Foundation of China and the self-selected project of China Academy of Chinese Medical Sciences. The findings are published in China Journal of Chinese Materia Medica, Issue 23, Volume 46, 2021, and the bilingual version is available online.

Corresponding Author: XIU Chengkui
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CNKI Press Officer: LI Jingjing YANG Na
Email: ljj6806@cnki.net yn6791@cnki.net

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