Baicalein regulates Rho-ROCK-MLC pathway to inhibit the growth and metastasis of breast cancer

Jun. 22,2022
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Breast cancer is a phenomenon in which breast epithelial cells proliferate out of control in response to multiple carcinogenic factors. The early stage of the breast cancer often shows symptoms such as breast lumps, nipple overflow and swollen axillary lymph nodes, etc. In advanced stage, multiple organ diseases may occur due to metastasis of cancer cells, which can directly threaten the life of patients and is one of the most common malignant tumors among women. Although there have been significant advances in early screening, surgery and radiotherapy and chemotherapy techniques for breast cancer, there is a lack of safe and effective clinical agents for the treatment of systemic metastases from advanced breast cancer. In recent years, more and more traditional Chinese medicine and their active ingredients have been reported to have the effect of inhibiting breast cancer cell metastasis, which has become one of the research hotspots in the development of drugs for the treatment of breast cancer. Baicalein is one of the main bioactive components of the Chinese herb Scutellariae radix, which has been shown to have antitumor, anti-inflammatory, anti-cardiovascular and antibacterial activities in both in vitro and in vivo studies. Baicalein can inhibit the proliferation of tumor cells, induce apoptosis of low toxic cancer cells and autophagic cell death, and so on, which has attracted more and more attention in the direction of inhibiting the metastasis of breast cancer.

Cai et al. from Shanghai University of traditional Chinese medicine established a nude mouse model of human breast cancer cell MDA-MB-231 xenograft tumor. The effects of baicalein on tumor growth and lung metastasis in nude mice were studied in vivo. The effects of baicalein on the migration of MDA-MB-231 cells and the expression of F-actin and related proteins involved in cytoskeleton recombination were studied in vitro. The results showed that baicalin was able to inhibit the migration of MDA-MB-231 cells and the expression of cytoskeletal protein F-actin through regulating the RhoA-ROCK-MLC signaling pathway, thereby inhibiting tumor growth, reducing the number of lung metastatic nodules and metastases, and exerting anti-breast cancer effects.

The related research was completed by Fei-Fei Cai, Xiu-Feng Wang, Qian-Mei Zhou, etc. Results are published in the 33rd volume, 4th issue of Natural Products Research and Development, 2021. The bilingual version has been launched.

Corresponding Author: SU Shibing
Email: shibingsu07@163.com
CNKI Press Officer: LI Jingjing YANG Na
Email: ljj6806@cnki.net yn6791@cnki.net

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